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KMID : 0363720020350060501
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Korean Journal of Anatomy
2002 Volume.35 No. 6 p.501 ~ p.507
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Are the Germinal Center T Cells the Memory Ones?.
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Lee Wang-Jae
Hwang Douk-Ho
Kim Joong-Gon
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Abstract
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Germinal center (GC) is a critical site where the humoral immune responses take place. Especially memory cells are known to be generated from the GC. In this experiment, T cells observed in the GC were studied in the aspect of memory T cells.
T cells responding to myelin basic protein (MBP) antigen usually have their own specific T cell receptor complex (TCR) consisting of Vα2and Vβ8. Therefore, MBP antigen enables to trace specific T cells reacting to MBP antigen.
This experiment, in which balb/c mice were injected with MBP into footpad and the popliteal lymph nodes were removed, showed that most of Vα2+ cells were L3T4+ cells, and that initially they were located in the deep cortex near the B cell follicles and later they were observed in the GC. In case of the primary injection of MBP, IL-4+ cells were observed for the first time, followed by appearance of CD69 and CD2R. In case of the secondary injection, all of IL-4, CD25, CD69, CD2R and CTLA-4 were observed from the 1st day after injection. However IL-4, CD25 and CD69 among them were not observed any more since 2 wks after the secondary injection.
These results strongly suggest that T cells observed in the GC during the immune responses for MBP might be memory T helper cells.
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KEYWORD
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Germinal center, Memory T cells, Surface markers for memory T cells
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